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weaning off effexor side effects

Indications for use:

Treatment of depression with concomitant anxiety also relapse prevention, including with rekurrentnom depressive disorder (in hospital or in an outpatient setting).

After the one-time admission Depot Cmax Effexor and its active metabolite are achieved for 5.5 and 9 h, respectively. Reception with food product does not give impact on the absorption and biotransformation of Effexor. Linking blood plasma Effexor and its metabolite is 27% and 30% respectively.
Metabolism and excretion
Effexor under action of P450 CYP2D6 largely biotransformiroetsa in the liver with the formation of the active metabolite, o-desmetilvenlafaksina. Effexor and its metabolites are excreted mainly kidneys. Approximately 87% of dose for 48 hours return with urine, 5% in an unmodified form, 29% in the form of unconjugated-desmetilvenlafaksina, 26% in the form of a conjugated o-desmetilvenlafaksina and 27% as other metabolites.
Pharmacokinetics in special clinical cases
The age and gender of the patients have no influence on the pharmacokinetic parameters of the product.
In patients with impaired liver (c cirrhosis in the stage of compensation) decreased metabolism of Effexor and its active metabolite, resulting in an increase in their concentration in the blood plasma.
In patients with moderately severe or severe disabilities kidney function decline clearance and an increase in the T1/2 Effexor and o-desmetilvenlafaksina. Reduce the overall clearance was more pronounced in patients with endogenous creatinine is its below 30 mL/min.

overdose effexor xr

The recommended initial dose Depot is 75 mg 1 time per day.
If necessary, the daily dose can be gradually increased to a maximum of 225 mg/SUT. The interval between dose increases Efektina Depot can be 2 weeks or more, but not less than 4 days.

Effexor contraindications:

-the simultaneous admission of MAO inhibitors and the period up to 14 days later for their lifting;
-pregnancy;
-lactation (breastfeeding);
-child and adolescence to 18 years;
-high sensitivity to the product.
Therapy Efektinom Depot must stop not less than 7 days prior to the use of MAO inhibitors.

Pregnancy and lactation:

The drug is contraindicated for use in pregnancy, because clinical data to substantiate the safety of its use.
When necessary, the appointment of Efektina Depot in the lactation period to decide the question of the cessation of breastfeeding as Effexor and its active metabolite stand out with breast milk.
If the product is used immediately before childbirth, it is necessary to take into account the possibility of product withdrawal symptoms in the newborn.

Special instructions:

The caution should appoint patients with product recently experienced myocardial infarction or unstable angina.
During the period of Efektina Depot to control HELL, because in some cases there is a dose-dependent increase in hell.
Be wary appoint patients with convulsions product in history.
Be wary appoint Efectin Depot patients whose HEART RATE increase can worsen the condition of the ill, since using large doses may increase HEART RATE. With caution and under careful medical supervision Efectin Depot appoint patients with increased vnutriglaznam pressure or at risk of developing acute attack zakratougolna glaucoma, as Effexor can induce Mydriasis.
A small number of patients with mood disorders receiving antidepressants (including Efectin Depot), there may be a mania or hypomania. Be wary appoint patients with manic State product in history.
Against the backdrop of Efektina Depot may develop hyponatremia or syndrome of inappropriate secretion of ADH (particularly in patients with gipovolemiei, including the elderly or taking diuretics).
The caution should appoint Efectin Depot predisposed patients with skin and mucous membranes.
In clinical trials, there were no signs of addiction, the development of tolerance or the need for increasing doses of the product over time.
In a dramatic admission of the product, while reducing the dose or in some cases when phasing out, you may experience the following symptoms: hypomania, anxiety, anxiety causing high nervous anxiety, confusion, insomnia, sleep disorders, high fatigue, drowsiness, parestesia, dizziness, headache, increased sweating, dry mouth, anorexia, diarrhea, nausea, vomiting. Most of these reactions are expressed nekordinal?no and do not require treatment.
When treating patients with depression should always take into account the risk of suicide attempts. To reduce the likelihood of an overdose, patients at the beginning of therapy, it was necessary to issue a minimum number of hands on the product.
Special recommendations on use of the product Efectin Depot in the elderly do not.
Against the backdrop of Efektina Depot should not consume alcohol.
Use in Pediatrics
The drug is contraindicated for use in kids and teens under the age of 18 years due to insufficient clinical data on efficacy and safety of its use in patients of this age group.

effexor 75 mg xr

In clinical trials, there were no signs of addiction, the development of tolerance or increase the dose over time. In vitro studies have been shown that Effexor has virtually no affinity for opioid receptors, benzodiazepinovym and also receptors phencyclidine, or N-methyl-D-Alpha-aminoantarnoj acid. Studies on laboratory animals (rodents) Effexor had no stimulating action on the central nervous system. Studies on primates received no evidence of clinically significant exciting or depressing the CENTRAL NERVOUS SYSTEM effects.
Impact on the ability to drive a car and management mechanisms
Asked about the possibility of activities potentially hazardous activities that require increased attention and psychomotor speed reactions, only to decide later assess individual patient reaction product.

Overdose:

Symptoms: ECG changes (extension QT interval, blockade feet beam Guisa, expansion of micro), sinus and ventricular tachycardia, aetiology, arterial gipotenzia, dizziness, impaired consciousness of varying degrees of severity, convulsions until death.
Treatment: washing stomach reception activated carbon, control functions of the cardiovascular system and other vital organs. Specific antidote not. Efficacy of forced diuresis, dialysis, hemoperfusion, and exchange transfusion are not proven.
During the postmarketingovyh product research Efectin Depot overdose mainly marked on the background of alcohol and other drugs.

Prescribed drug interaction:

If you use with MAO inhibitors may develop severe side effects (tremor, myoclonus, increased sweating, nausea, vomiting, dizziness, redness, hyperthermia and symptoms similar to CSN, convulsions until death). This combination is contraindicated.
If you use Efectin Depot strengthens antikoagulyazionny effect of warfarin.
If you have not found the interaction between diazepam and its active metabolite-desmetildiazepamom and Effexor or o-desmetilvenlafaksinom.